• Burkholderia pseudomallei PenI β-lactamase and Variants Are Potently Inhibited by Taniborbactam

    Maria Mojica, Scott Becka, Mitchell Edwards, Cullen Myers, Kyoko Uehara, Tsuyoshi Uehara, Tyuji Hoshino, Elise Zeiser, Cassandra Chatwin, David Six, Robert Bonomo, Krisztina Papp-Wallace, Michiyoshi Nukaga

    Antimicrobial Agents and Chemotherapy. (Accepted)

  • A new class of penicillin-binding protein inhibitors to address drug-resistant Neisseria gonorrhoeae

    Tsuyoshi Uehara, Allison L Zulli, Brittany Miller, Lindsay M Avery, Steven A Boyd, Cassandra L Chatwin, Guo-Hua Chu, Anthony S Drager, Mitchell Edwards, Susan G Emeigh Hart, Cullen L Myers, Gopinath Rongala, Annie Stevenson, Kyoko Uehara, Fan Yi, Bibo Wang, Zhenwu Liu, Mingyue Wang, Zhichao Zhao, Xinming Zhou, Haiyan Zhao, Rok Tkavc, Ann E Jerse, Caleb M Stratton, Sandeepchowdary Bala, Christopher Davies, Daniel C Pevear, Christopher J Burns, Denis M Daigle, Stephen M Condon

    bioRxiv 2024.12.27.630553; doi: https://doi.org/10.1101/2024.12.27.630553. (under review)

  • Cefepime-Taniborbactam and Ceftibuten-Ledaborbactam Maintain Activity Against KPC Variants that Lead to Ceftazidime-Avibactam Resistance

    Cullen L Myers*, Annie Stevenson, Brittany Miller, Denis M Daigle, Tsuyoshi Uehara, Daniel C Pevear

    *: Corresponding authour

    Antimicrob Agents Chemother (2025) 0:e01511-24. doi: https://doi.org/10.1128/aac.01511-24

  • Microbiological characterization of VNRX-5236, a broad-spectrum β-lactamase inhibitor for rescue of the orally bioavailable cephalosporin ceftibuten as a carbapenem-sparing agent against strains of Enterobacterales expressing extended-spectrum β-lactamases and serine carbapenemases

    Cassandra L Chatwin, Jodie C Hamrick, Robert EL Trout, Cullen L Myers, Susan M Cusick, William J Weiss, Mark E Pulse, Luigi Xerri, Christopher J Burns, Gregory Moeck, Denis M Daigle, Kaitlyn John, Tsuyoshi Uehara, Daniel C Pevear

    Antimicrob Agents Chemother (2021) 65:10.1128/aac.00552-21. doi: https://doi.org/10.1128/aac.00552-21

  • VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosaw List Item

    Jodie C Hamrick, Jean-Denis Docquier, Tsuyoshi Uehara, Cullen L Myers, David A Six, Cassandra L Chatwin, Kaitlyn J John, Salvador F Vernacchio, Susan M Cusick, Robert EL Trout, Cecilia Pozzi, Filomena De Luca, Manuela Benvenuti, Stefano Mangani, Bin Liu, Randy W Jackson, Greg Moeck, Luigi Xerri, Christopher J Burns, Daniel C Pevear, Denis M Daigle

    Antimicrob Agents Chemother (2020) 64:10.1128/aac.01963-19. doi: https://doi.org/10.1128/aac.01963-19

  • A cell-based approach to characterize antimicrobial compounds through kinetic dose responsetem

    Craig R MacNair, Jonathan M Stokes, Shawn French, Cullen L Myers, Kali R Iyer, Eric D Brown

    Bioorg Med Chem (2016) 24 (24), 6315-6319. doi: https://doi.org/10.1016/j.bmc.2016.09.053

  • Identification of two phosphate starvation-induced wall teichoic acid hydrolases provides first insights into the degradative pathway of a key bacterial cell wall component

    Cullen L Myers, Franco KK Li, Byoung-Mo Koo, Omar M El-Halfawy, Shawn French, Carol A Gross, Natalie CJ Strynadka, Eric D Brown

    J Biol Chem (2016), Volume 291, Issue 50, 26066 - 26082. doi: https://doi.org/10.1074/jbc.M116.760447

  • Functional roles in S-adenosyl-L-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase

    Cullen L Myers, Emily G Kuiper, Pei C Grant, Jennifer Hernandez, Graeme L Conn, John F Honek

    FEBS lett (2015) 589 (21), 3263-3270. doi: https://doi.org/10.1016/j.febslet.2015.09.028

  • Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

    Maya A Farha, Tomasz L Czarny, Cullen L Myers, Liam J Worrall, Shawn French, Deborah G Conrady, Yang Wang, Eric Oldfield, Natalie CJ Strynadka, Eric D Brown

    Proc. Natl. Acad. Sci. U.S.A.(2015) 112 (35) 11048-11053. doi: https://doi.org/10.1073/pnas.1511751112

  • Characterization of wall teichoic acid degradation by the bacteriophage ϕ29 appendage protein GP12 using synthetic substrate analogs

    Cullen L Myers, Ronald G Ireland, Teresa A Garrett, Eric D Brown

    J Biol Chem (2015), Volume 290, Issue 31, 19133 - 19145. doi: https://doi.org/10.1074/jbc.M115.662866

  • Molecular Interactions between Thiostrepton and the TipAS Protein from Streptomyces lividans

    Cullen L Myers, Jesse Harris, Jacky CK Yeung, John F Honek

    ChemBioChem, 15: 681-687 (2014) https://doi.org/10.1002/cbic.201300724

  • Semi-synthetic analogues of thiostrepton delimit the critical nature of tail region modifications in the control of protein biosynthesis and antibacterial activity

    Cullen L Myers, Pei C Hang, Grace Ng, Joshua Yuen, John F Honek

    Bioorg Med Chem 18 (12), 4231-4237 (2010) doi: https://doi.org/10.1016/j.bmc.2010.04.098